Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

A spinning disk apparatus for producing microparticles comprising a substantially circular spinning disk, wherein the spinning disk comprises:

• (A) an inner peripheral edge;
• (B) an outer peripheral edge;
• (C) a substantially smooth annular disk surface extending between the inner peripheral edge and the outer peripheral edge, wherein
• (i) the outer peripheral edge defines a first diameter of the annular disk surface,
• (ii) the annular disk surface has a second diameter defined by the area circumscribed by the inner peripheral edge, wherein the area circumscribed by the inner peripheral edge is disposed substantially in a center portion of the spinning disk, and
• (iii) the annular disk surface extending between the inner peripheral edge and the outer peripheral edge comprises a substantially flat incline;
• and
• (D) a reservoir disposed in the area circumscribed by the inner peripheral edge of the annular disk surface, wherein
• (i) the reservoir comprises a top portion thereof defined by the second diameter, and
• (ii) the reservoir comprises a cross-sectional area defined by a third diameter, located between the bottom of the reservoir and the top portion of the reservoir, wherein the third diameter is greater than the second diameter.