Human FGF-21 polypeptides
AssigneesChiron Corporation, Kyoto University
InventorsNobuyuki Itoh, W Michael Kavanaugh
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Abstract
This invention relates to human fibroblast growth factor (hFGF-21), and to variants thereof and to polynucleotides encoding FGF-21. The invention also relates to diagnostic and therapeutic agents related to the polynucleotides and proteins, including probes and antibodies, and to methods of treating liver disease such as cirrhosis and cancer, methods of treating conditions related to thymic function, and methods of treating conditions of the testis. The invention also relates to mouse fibroblast growth factor (mFGF-21), and to variants thereof and polynucleotides encoding mFGF-21.
Claims3
An epitope-bearing portion of the polypeptide of SEQ ID NO:4 for producing an antibody that binds to the polypeptide of SEQ ID NO:
- 4, wherein said epitope consists of the amino acid sequence of SEQ ID NO:8.
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:
- 4.
An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.