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US 7,259,172 B2Granted
Inhibitors of β-lactamase
AssigneeMethylGene Inc.
InventorsJeffrey M. Besterman, Jubrail Rahil, Arkadii Vaisburg
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Abstract
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase inhibitors, which are structurally unrelated to the natural product and semi-synthetic β-lactamase inhibitors presently available, and which do not require a β-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiting bacterial growth.
Claims5
A compound of the following formula:
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is thien-2-yl, each optionally substituted;
- L is a covalent bond, —CH2O—, —C(O)—, or —C(═N—OCH3)—;
- and
- R5 is -halo or —OR10 wherein R10 is —H, phenyl, pyridinyl, or quinolinyl, each optionally substituted,
- provided that when L is —CH2O—, R5 is not —F or p-nitrophenoxy.
3 more elements
Dependencies are inferred from the claim text.