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US 7,258,873 B2Granted
Preservation of bioactive materials by spray drying
AssigneeMedImmune Vaccines, Inc.
InventorsVu Truong-Le, Binh Pham
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Abstract
This invention provides methods and compositions to preserve bioactive materials in a matrix of powder particles. Methods provide high-pressure gas spraying and/or near supercritical spraying of formulations followed by drying in a stream of conditioned gas to form stable powder particles containing bioactive materials.
Claims39
A method of preparing powder particles containing bioactive material, the method comprising:
- preparing a suspension or solution comprising the bioactive material;
- forming a mixture of the solution or suspension with a high pressure gas comprising a pressure ranging from about 250 psi to a pressure less than 90% of a critical pressure of the gas;
- reducing a pressure on the mixture, thereby spraying a biphasic gaseous suspension of droplets;
- and,
- drying the droplets into powder particles by exchanging a gas from the gaseous suspension of droplets with a drying gas.
2 more elements
Dependencies are inferred from the claim text.