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US 7,258,734 B2Granted
Injectable calcium phosphate cements and the preparation and use thereof
AssigneeCalcitec, Inc.
InventorsJiin-Huey Chern Lin, Chien-Ping Ju, Wen-Cheng Chen
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Abstract
A calcium phosphate cement suitable for use in dental and bone prosthesis is disclosed, which include calcium phosphate particles having a diameter of 0.05 to 100 microns, wherein said calcium phosphate particles on their surfaces have whiskers or fine crystals having a width ranging from 1 to 100 nm and a length ranging from 1 to 1000 nm.
Claims11
A method of forming calcium phosphate cement particles with calcium phosphate crystals on the surface of the particles comprising:
- forming a mixture by contacting calcium phosphate particles with an acidic wetting agent, wherein the calcium phosphate particles comprise tetracalcium phosphate and dicalcium phosphate anhydrous;
- subjecting the mixture to one or more controlling treatments, wherein at least one of the controlling treatments substantially removes the wetting solution from the mixture, and wherein the controlling treatment is chosen such that the treatment causes the growth of fine crystals or whiskers on the surface of at least a portion of the calcium phosphate particles;
- and
- reducing the size of the calcium phosphate particles such that the calcium phosphate particles have an average diameter ranging from 0.05 microns to 100 microns.
1 more element
Dependencies are inferred from the claim text.