Coherently controlled nonlinear Raman spectroscopy and microscopy
AssigneeYeda Research and Development Co. Ltd.
InventorsYaron Silberberg, Nirit Dudovich, Dan Oron
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Abstract
A method and system are presented for producing an output coherent anti-stokes Raman scattering (CARS) signal of a medium. The method comprises generation of a unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon; and inducing a CARS process in the medium by exciting the medium by the at least one such unitary optical excitation pulse.
Claims64
A method for producing an output Coherent Anti-Stokes Raman Scattering (CARS) signal of a medium, the method comprising:
- (a) producing a single pulse presenting a unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon;
- and
- (b) inducing a CARS process in the medium by exciting the medium by at least one said unitary optical excitation pulse, thereby enabling production of the CARS signal of the medium using the unitary optical excitation pulse.
A pulse creation method for use in Coherent Anti-Stokes Raman Scattering (CARS) spectroscopy or microscopy, the method comprising:
- utilizing a single laser operable to generate a transform limited optical pulse carrying a pump photon, a Stokes photon and a probe photon, and applying a predetermined shaping to the transform limited optical pulse to produce a unitary optical excitation pulse, thereby enabling application of said unitary optical excitation pulse to a medium to induce a CARS signal of the medium using the unitary optical excitation pulse.
A method for Coherent Anti-Stokes Raman Scattering (CARS) spectroscopy of a medium constituted of molecules capable of producing an output CARS signal, comprising:
- (a) producing at least one unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon;
- (b) focusing said at least one unitary optical excitation pulse onto the medium, thereby exciting the medium to produce the output CARS signal of the molecules, thereby enabling measurement of said output CARS signal.
A method for Coherent Anti-Stokes Raman Scattering (CARS) microscopy of a medium constituted of molecules producing an output CARS signal, the method comprising:
- producing at least one unitary optical excitation pulse that carries a pump photon, a Stokes photon and a probe photon;
- focusing said at least one unitary optical excitation pulse onto the medium, thereby exciting the medium to produce the output CARS signal of the molecules;
- providing a relative displacement between the medium and the exciting beam to thereby enable scanning of the medium by the unitary excitation pulse beam.
A system for use in measuring an output Coherent Anti-Stokes Raman Scattering (CARS) signal of a medium, the system comprising a single laser operable to generate at least one transform limited optical pulse carrying a pump photon, a Stokes photon and a probe photon, and a programmable pulse shaper for receiving the transform limited optical pulse and shaping it to produce a unitary optical excitation pulse.
A system for measuring an output Coherent Anti-Stokes Raman Scattering (CARS) signal of a medium under investigation, comprising
- a single laser operable to generate at least one transform limited optical pulse carrying a pump photon, a Stokes photon and a probe photon;
- a programmable shaping assembly operable to receive the at least one transform limited optical pulse and produce therefrom a unitary optical excitation pulse carrying the pump, Stokes and probe photons;
- a detector unit for receiving the output CARS signal produced by the medium excited by said unitary optical excitation pulse, and generating data indicative thereof;
- and
- light directing optics for directing the unitary optical excitation pulse to the medium and directing the output CARS signal to the detector unit.
Dependencies are inferred from the claim text.