Process for producing β-hydroxyester
AssigneeDaiso Co., Ltd.
InventorsKimitaka Igi, Yoshiro Furukawa, Keishi Takenaka
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Abstract
A process for producing a β-hydroxyester by reacting an epoxide, an alcohol and carbon monoxide in the presence of a cobalt carbonyl compound as catalyst, which is characterized in using as co-catalyst, a pyridine derivative having an amino substituent of formula (1), wherein R1 and R2 are independently hydrogen, formyl, acyl, alkoxycarbonyl, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or R1 and R2 may be taken together with the adjacent nitrogen atom to form a ring, and n is an integer of 1 or 2.
Claims13
A process for preparation of a β-hydroxyester which comprises reacting an epoxide, an alcohol and carbon monoxide in the presence of a cobalt carbonyl compound as catalyst, and as co-catalyst, a pyridine derivative having an amino substituent group represented by the following formula (1),
- wherein R1 and R2 are independently hydrogen atom, formyl group, acyl group, alkoxycarbonyl group, substituted or unsubstituted alkyl group, substituted or unsubstituted aralkyl group, substituted or unsubstituted aryl group, or R1 and R2 may be taken together with the adjacent nitrogen atom to form a ring, and n is an integer of 1, the amino substituent group is at position 4 of the pyridine ring, and said pyridine ring is unsubstituted or substituted by C1 to 6 alkyl group or may be fused at its positions 2 and 3 with a benzene ring.
Dependencies are inferred from the claim text.