Apoptin-associating protein
AssigneeLeadd B.V.
InventorsMathieu Hubertus M. Noteborn, Astrid Adriana A. M. Danen-van Oorschot, Jennifer Leigh Rohn, Bertram Weiss, Luisella Toschi
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Abstract
The invention relates to the field of apoptosis. The invention provides novel therapeutic possibilities, for example novel combinatorial therapies or novel therapeutic compounds that can work alone, sequentially to, or jointly with Apoptin, especially in those cases wherein p53 is (partly) nonfunctional.
Claims12
An isolated or recombinant nucleic acid sequence encoding an Apoptin-associating proteinaceous substance that localizes in the nucleus of a cell and induces apoptosis, the isolated or recombinant nucleic acid sequence being at least 95% homologous to SEQ ID NO:
- 10 or SEQ ID NO:
- 13.
A composition comprising a nucleic acid sequence that is at least 95% homologous to a nucleic acid sequence of SEQ ID NO:
- 10 or SEQ ID NO:
- 13, wherein said composition induces apoptosis.
Dependencies are inferred from the claim text.