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US 7,256,258 B2Granted
Regioselective liquid phase pegylation
AssigneeAres Trading S.A.
InventorsGilles Piquet, Luca Barbero, Silvio Traversa, Monica Gatti
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Abstract
A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys12. This method is characterized in that the reaction is carried out in a structuring solvent, such as trifluorethanol.
Claims5
A method for the liquid-phase regioselective synthesis of a GRF-PEG conjugate having one PEG unit covalently bound to the ε amino group of Lys12, comprising conjugating the GRF peptide and an activated PEG in a structuring solvent consisting of trifluoroethanol.
Dependencies are inferred from the claim text.