Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions

An immunomodulatory peptide construct with the formula

• P1−X−P2
• where P1 is a peptide associated with autoimmune disease, allergy or asthma, or host-versus-graft rejection and which binds to an antigen receptor on a set or subset of T cells;
• P2 is an immune modulating peptide which (i) causes a directed immune response by said set or subset of T cells to which the peptide P1 is attached or bound or (ii) binds to a T cell receptor which causes said set or subset of T cells to which the peptide P1 is bound to initiate, but not complete, an immune response causing said set or subset of T cells to undergo anergy and apoptosis;
• and x is a direct bond or linker for covalently bonding P1 and P2
• wherein peptide P1 is selected from the group consisting of SEQ ID NO:
• 1, SEQ ID NO:
• 2, SEQ ID NO:
• 3, SEQ ID NO:
• 16, SEQ ID NO:
• 19, SEQ ID NO:
• 40, SEQ ID NO:
• 41, SEQ ID NO:
• 42, SEQ ID NO:
• 43, SEQ ID NO:
• 44, SEQ ID NO:
• 45, SEQ ID NO:
• 46, SEQ ID NO:
• 47, SEQ ID NO:
• 48 and SEQ ID NO:
• 49
• wherein peptide P2 is selected from the group consisting of SEQ ID NO:
• 4, SEQ ID NO:
• 5, SEQ ID NO:
• 6, SEQ ID NO:
• 13, SEQ ID NO:
• 15, SEQ ID NO:
• 50, SEQ ID NO:
• 18, SEQ ID NO:
• 21, SEQ ID NO:
• 24, and SEQ ID NO:
• 28 and SEQ ID NO:
• 51.