Monocyclic N-Aryl hydantoin modulators of androgen receptor function

A Compound according to Formula I:

• wherein:
• R1 and R2 are each independently selected from the group consisting of H, substituted alkyl, alkenyl, substituted alkenyl, substituted arylalkyl, arylalkel and substituted arylalkenyl, or wherein R1 and R2 may be taken together to form a carbon-carbon double bond that is optionally substituted with one or more substituents chosen from the group consisting of H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, arylalkyl, substituted arylalkyl, arylalkenyl and substituted arylalkenyl;
• R3 is H;
• X is selected from the group consisting of O or NR1;
• G is a phenyl group, wherein said phenyl group is substituted with 4-CN, and said phenyl group is optionally substituted with one or more substituents selected from the group consisting of H, halo, CN, CF3, OR4, CO2R4, NR4R4′, CONR4R4′, CH2OR4, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl and heteroaryl or substituted heteroaryl;
• R4 and R4′ in each functional group are each independently selected from the group consisting of H, alkyl or substituted alkyl, alkenyl or substituted alkenyl, alkynyl or substituted alkynyl, cycloalkyl or substituted cycloalkyl, arylalkyl or substituted arylalkyl, aryl or substituted aryl, and heteroaryl or substituted heteroaryl;
• and
• with the following provisos:
• (a) when R1 and R2 are each CH3, G is not an aryl, wherein both ortho positions of the aryl are H;
• and
• (b) when G is
• R1 is H.