Bicyclic compounds and compositions

A compound of Formula I:

• wherein:
• Y is —CH2CH2—, —CH2CH(OH)—, —CH(OH)CH2—, —C(O)CH2—, —CH2C(O)—, —CH═CH— or 1,2-cyclopropylene;
• X is arylene or C5-6heteroarylene optionally substituted by one to three substituents selected from halo, C1-10alkyl and halo-substituted C1-6alkyl;
• R1 is a group of formula (a), (b), (c), (d), (e) or (f):
• in which n is 0, 1, 2, 3, 4 or 5;
• m is 0, 1 or 2;
• R6 is C1-10alkyl, cycloalkyl, C1-10alkoxy, C2-10alkenyl, C2-10alkynyl, C1-10alkylthio, C1-10alkylsulfonyl, C1-10alkylsulfinyl or halo-substituted-C1-10alkyl;
• in each of which any aliphatic part of the group can be straight chain or branched and can be optionally substituted by up to three hydroxy, cycloalkyl, or C1-4alkoxy groups and optionally interrupted by a double or triple bond or one or more C(O), NR12, S, S(O), S(O)2 or O groups,
• R7 is aryl or C5-6heteroaryl optionally substituted by aryl, C5-6heteroaryl or C3-8heterocycloalkyl wherein any aryl, heteroaryl or heterocycloalkyl group of R7 can be optionally substituted by one to three substituents selected from halogen, C1-10alkyl, C1-10alkoxy, halo-substituted-C1-10alkyl and halo-substituted-C1-10alkoxy;
• R2 is hydrogen;
• C1-4alkyl optionally substituted with one or more halogens;
• C2-6 alkenyl, C2-6alkynyl, or cycloalkyl optionally substituted by halogen;
• or C1-4alkyl optionally substituted on the terminal C atom by OH or a residue of formula (g):
• in which Z is O, S, (CH2)1-2, CF2 or NR11 where R11 is H, (C1-4)alkyl or halo substituted (C1-4)alkyl;
• and R9 and R10, independently, are H, OH, (C1-4)alkyl optionally substituted by one to three halo groups, or (C1-4)alkoxy;
• with the proviso that R9 and R10 are not both hydrogen;
• R3 and R4, independently, are H or C1-4alkyl optionally substituted by halogen or acyl;
• and R5 is —OH, —Oacyl, —NHacyl, or a residue of formula (g) as defined above;
• or a salt thereof.