Method and composition for potentiating an oplate analgesic
AssigneeThe Board of Trustees of the University of Illinois, a body corporate and politic of the State of Illinois
InventorZaijie Wang
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Abstract
Composition and methods of treating pain and reducing, reversing, or preventing tolerance to opiate analgesics are disclosed. The composition and method utilize an opiate analgesic and a calcium calmodulin kinase (CaMKII) inhibitor as active agents to treat pain in mammals, including humans.
Claims1
A method for reducing tolerance to an opiate analgesic in an individual undergoing opiate analgesic therapy comprising administering intrathecally to an individual an effective amount of KN93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine) which inhibits the activity of spinal calmodulin dependent protein kinase II.
Dependencies are inferred from the claim text.