Materials and methods for the treatment of depression
AssigneeARYx Therapeutics, Inc.
InventorPascal Druzgala
Life of this patent
Estimating the term…
Abstract
The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are methods of treating depression and affective disorders, such as obsessive compulsive disorder. Pharmaceutical compositions of the fluvoxamine analogs are also taught.
Claims6
A method for treating a disease state which can be improved by a serotonin reuptake inhibitor wherein said method comprises administering, to an individual in need of such treatment, a compound, or salt thereof, wherein said compound has the following structure
- and wherein
- R1 and R2 are independently H or C1-10 alkyl;
- or
- R1 and R2 are methylene groups that together form part of a cyclic structure;
- R3 is a linear or branched alkyl or heteroalkyl group having 1 to 12 carbon atoms;
- or
- R3 is heterocycloalkyl, benzyl, aryl, or heteroaryl optionally substituted with one or more halogen atoms C1-4 alkyl, C1-4 alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, trifluoromethyl,—
- COOH, or —COOC1-4 alkyl;
- X is fluoro, chloro, iodo, trifluoromethyl, methoxy, cyano, nitro, amino, mono- or di-substituted amino, carboxamide, carboxylic acid, carboxylic ester, sulfonic acid, methyl sulfonate, or sulfonamide;
- n is from 0 to 12, and
- Z=
A pharmaceutical composition comprising a compound, or a salt thereof, wherein said compound has the following structure:
- where R1 and R2 are independently H or C1-10 alkyl or R1 and R2 are methylene groups that together form part of a cyclic structure;
- R3 is a linear or branched alkyl or heteroalkyl group having 1 to 12 carbon atoms, or R3 is heterocycloalkyl, benzyl, aryl, or heteroaryl optionally substituted with one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, trifluoromethyl, —COOH, or —COOC1-4 alkyl;
- X is fluoro, chloro, iodo, trifluoromethyl, methoxy, cyano, nitro, amino, mono- or di-substituted amino, carboxamide, carboxylic acid, carboxylic ester, sulfonic acid, methyl sulfonate, or sulfonamide;
- n is from 0 to 12, and
- Z is selected from the group consisting of:
A compound, or salt thereof, wherein said compound has the following structure:
- where:
- R1 and R2 are independently H or C1-10 alkyl or R1 and R2 are methylene groups that together form part of a cyclic structure;
- R3 is a linear or branched alkyl or heteroalkyl group having 1 to 12 carbon atoms, or R3 is heterocycloalkyl, benzyl, aryl, or heteroaryl optionally substituted with one or more halogen atoms, C1-4 alkyl, C1-4 alkoxy, hydroxy, cyano, amino, alkylamino, dialkylamino, trifluoromethyl, —COOH, or —COOC1-4 alkyl;
- X is fluoro, chloro, iodo, trifluoromethyl, methoxy, cyano, nitro, amino, mono- or di-substituted amino, carboxamide, carboxylic acid, carboxylic ester, sulfonic acid, methyl sulfonate, or sulfonamide;
- n is from 0 to 12, Z=—CH2—CH2—N(R6R7) where R6 and R7 are independently H or lower alkyl, or R6 and R7 are methylene groups that together with the nitrogen form a cyclic structure;
- or Z=
- where m=1 or 2 and R8 is H or lower alkyl.
Dependencies are inferred from the claim text.