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US 7,256,176 B2Granted
Methods of modulating β cell function
AssigneeJoslin Diabetes Center, Inc.
InventorsEleftheria Maratos-Flier, Rohit N. Kulkarni, Pavlos Pissios
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Abstract
Methods of modulating pancreatic function by modulating MCH signaling in a β cell.
Claims17
A method of promoting β cell function or development, selected from the group consisting of increasing insulin secretion, β cell size, and β beta cell growth the method comprising contacting a β cell with an effective amount of an agonist of melanocyte concentrating hormone (MCH), wherein the agonist comprises MCH or a peptide analog of MCH comprising the sequence VYRPC (amino acids 12-16 of SEQ ID NO:1), wherein the agonist has MCH activity in a fish skin teleost bioassay.
Dependencies are inferred from the claim text.