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US 7,256,172 B1Granted
Method of treatment and agents useful for same
AssigneeThe University of Melbourne
InventorsThomas Matthew Cocks, James David Moffatt
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AssigneeThe University of Melbourne
InventorsThomas Matthew Cocks, James David Moffatt
Estimating the term…
The present invention relates generally to a method of inducing, stimulating or otherwise facilitating bronchoprotection in humans and animals by modulating bronchial constriction and/or inflammation. The present invention is predicated in part on the identification of receptors in airway epithelium which mediate inhibition of bronchoconstriction and/or inflammation following their activation. More particularly, the present invention identifies that activation of protease activated receptors (PARs) results in relaxation of airway epithelium. Activation of airway epithelium PARs inhibits bronchoconstriction and/or inflammation and thereby mediates bronchoprotection of the airways. The present invention further provides a method for the prophylaxis and treatment of disease conditions in airways such as asthma and bronchitis and further provides methods for the diagnosis and screening of agents useful in the prophylaxis and treatment of airway disease conditions.
A method for mediating relaxation of an airway of an animal, said method comprising administering to said animal, an amount of a peptide effective for mediating relaxation of said airway, said peptide having a sequence comprising SLIGRL (SEQ ID NO:2) or a peptide analog thereof in which an amino acid is replaced with a non-natural amino acid, wherein said peptide is capable of activating an airway epithelium protease activated receptor-2 (PAR2) under conditions sufficient for activation of said PAR2 to occur, thereby mediating relaxation of said airway.
A method of identifying an agent for treatment or prophylaxis of inflammation of an airway of an animal, comprising:
A method for treatment of inflammation of an airway of an animal, said method comprising administering to said animal, an amount of a peptide effective for treatment of inflammation, said peptide having a sequence comprising SLIGRL (SEQ ID NO:2) or a peptide analog thereof in which an amino acid is replaced with a non-natural amino acid, wherein said peptide is capable of activating an airway epithelium protease activated receptor-2 (PAR2) under conditions sufficient for activation of said PAR2 to occur, thereby providing said treatment of inflammation.
Dependencies are inferred from the claim text.