Core-shell metal particles coated with dextran or aminodextran carrying SH groups, and use thereof
AssigneeRoche Diagnostics Operations, Inc.
InventorsPeter Sluka, Sebastian Heimerl, Konrad Kuerzinger, Thomas Fischer
Life of this patent
Estimating the term…
Abstract
Colloidal metal particles having a coating comprising non cross-linked, SH-activated dextran or aminodextran. Biomolecules may be linked directly or indirectly to the particles, which are useful as detection reagents in immunological assays.
Claims15
A core-shell particle comprising a colloidal metal particle surrounded by a shell wherein the shell comprises non cross-linked dextran or non cross-linked aminodextran wherein said dextran or aminodextran is modified to carry SH groups.
A method for producing a core-shell particle comprising a colloidal metal particle surrounded by a shell wherein the shell comprises non cross-linked dextran or non cross-linked aminodextran wherein said dextran or aminodextran is modified to carry SH groups, the method comprising:
- a) modifying dextran or aminodextran by inserting SH groups, and
- b) coating colloidal metal particles with the SH-modified aminodextran from step (a).
Dependencies are inferred from the claim text.