US 7,256,045 B2Granted

Analyzer with sample quality measurement, and method

AssigneeOrtho-Clinical Diagnostics, Inc.

InventorsMerrit N. Jacobs, James D. Shaw

Life of this patent

Estimating the term…

Loading patent…

Abstract

A system for detecting and analyzing patient sample quality and/or analytes, while the sample is in the metering tip used to aspirate the sample liquid from an original patient sample container, and also to dispense the liquid onto a slide test element. Spectrophotometric analysis may be done on the sample liquid while it is still in the tip which has been converted into a cuvette. One technique for such analysis is by scanning the cuvette for transmittance in a light-tight enclosure. Near-infrared and adjacent visible radiation may be used, and the absorption spectra of the liquid detected and analyzed. A possible aspect of the present invention relates to enhancing throughput of an analyzer by conducting a sample quality measurement in a process that is parallel to the main analyzer timing cycle. Another possible aspect of the present invention relates to improving performance of the analyzer by sealing the end of the metering tip to spontaneously form a cuvette for holding the sample during the sample quality measurement. Some advantages of the present system and method include improved throughput, the capability to use smaller sample liquid volumes, eliminating any need for a separate supply of cuvettes independent of the metering tips, and providing for detection through a cone of the metering tip rather than through any label, compared to doing the scanning of the sample liquid in a primary patient collection container.

Claims1

Dependent claims

A clinical analyzer for analyzing at least a portion of a liquid sample, comprising:

sample handling apparatus having one or more sample containers holding an amount of sample liquid;
sample metering apparatus having a proboscis defining a metering lumen, one or more tips with a tubular shape and a metering aperture at one end, and a metering pump coupled with the proboscis lumen;
the tips being removably attachable to the proboscis and allowing fluid communication between the metering pump and the metering aperture through the proboscis lumen;
sample processing apparatus having one or more test elements, an incubator and at least a thin film clinical chemistry system and a wet chemistry clinical testing system for conducting clinical tests on the liquid samples;
and
sample quality apparatus having a spectrophotometer and a tip end clamping device;
the analyzer having several operating stations:
(a) an initial aspiration position where a metering aperture of the tip can be periodically immersed in sample liquid held within one of the sample container;
the metering pump adapted to create a partial vacuum to cause a selected volume of sample liquid to be aspirated from a sample container into the tip;
(b) a dispensing position where the metering pump can create a partial pressure to cause a portion of the sample liquid to be dispensed from the tip onto a test element;
(c) a thin film clinical chemistry testing position;
(d) a sample quality measurement position;
and
(e) a wet chemistry testing position.

11 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/940,915Filed 14 Sep 2004 · division
Priority: 11 Sep 2000
Published: US 2005/0054112 A110 Mar 2005
Granted: 14 Aug 2007
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

G01N 35/00594
Control arrangements for automatic analysers: quality control, including calibration or testing of components of the analyser
G01N 35/00603
Quality control, including calibration or testing of components of the analyser: reinspection of samples
G01N 35/10
Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor:…
G01N 2035/1055
Using the transfer device for another function: for immobilising reagents, e.g. dried reagents