PRO4405 nucleic acids
AssigneeGenentech, Inc.
InventorsLuc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
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Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims15
An isolated nucleic acid having at least 95% nucleic acid sequence identity to:
- (a) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:45;
- (b) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:45, lacking its associated signal peptide;
- (c) the nucleic acid sequence of SEQ ID NO:44;
- (d) the full length coding sequence of the nucleic acid sequence of SEQ ID NO:44;
- or
- (e) the full-length coding sequence of the eDNA deposited under ATCC accession number 203966;
- and
- wherein said isolated nucleic acid encodes a polypeptide that has the ability to induce chondrocyte redifferentiation.
An isolated nucleic acid comprising:
- (a) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:45;
- (b) a nucleic acid sequence encoding the polypeptide of SEQ ID NO:45, lacking its associated signal peptide;
- (c) the nucleic acid sequence of SEQ ID NO:44;
- (d) the full length coding sequence of the nucleic acid sequence of SEQ ID NO:44;
- or
- (e) the full-length coding sequence of the eDNA deposited under ATCC accession number 203966.
Dependencies are inferred from the claim text.