Inhibitor of cell proliferation and methods of use thereof
AssigneeNucleus Remodeling, Inc.
InventorJoseph Edward Zahner
Life of this patent
Estimating the term…
Abstract
An chimerical polypeptide that arrests proliferating cells in mitosis is provided. In general the polypeptide has an N-terminal transit peptide, such as HIV-1 Tat, and a C-terminal cell-cycle effector, such as a G2/M cyclin or a cytostatic factor. A polynucleotide under the control of a heterologous promoter that encodes a polypeptide that arrests cells in mitosis is also provided. The polynucleotide may, for example, encode a G2/M cyclin. Pharmaceutical compositions comprising the agent that inhibits transit through mitosis is provided. A method of treating patients suffering from a hyperplasia, such as cancer, psoriasis or benign prostate hyperplasia is provided.
Claims6
An isolated polynucleotide comprising a nucleic acid encoding the polypeptide sequence set forth in SEQ ID NO:22.
A Pichia pastoris cell comprising a polynucleotide sequence that encodes a polypeptide sequence comprising SEQ ID NO:22.
Dependencies are inferred from the claim text.