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US 7,256,024 B2Granted
Tyrissamycin antibiotic
AssigneeBristol-Myers Squibb Company
InventorsJingfang Q. Cutrone, Lyndon M. Foster, Kimberly D. Krampitz, Stephen W. Mamber, Grace A. McClure, Todd C. Peterson, Lisa C. Rupar, Katie A. Thompson
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Abstract
A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
Claims2
A process for the preparation of tyrissamycin having the following characteristics:
- (a) a white amorphous powder;
- (b) soluble in chloroform, dimethylsulfoxide and methanol, and essentially insoluble in water;
- (c) has an ultraviolet absorption spectrum when dissolved in methanol substantially as shown in FIG. 1;
- (d) has an infrared absorption spectrum (KBr) substantially as shown in FIG. 2;
- (e) has a proton magnetic resonance spectrum in CD3OD substantially as shown in FIG. 3;
- and
- (f) has a 13C magnetic resonance spectrum in CD3OD substantially as shown in FIG. 4;
- which comprises cultivating Streptomyces lividans ATCC-202143 under submerged aerobic conditions in an aqueous nutrient medium containing assimilable sources of carbon and nitrogen until a substantial amount of tyrissamycin is produced by said organism in said culture medium.
5 more elements
Dependencies are inferred from the claim text.