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US 7,256,021 B2Granted
Enterobacteriaceae strains with an attenuated aspA gene for the fermentative production of amino acids
AssigneeDegussa AG
InventorThomas Hermann
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Abstract
The invention relates to a process for the preparation of L-amino acids, especially L-lysine, L-valine, L-homoserine and L-threonine, by fermenting a microorganism of the genus Escherichia which has a mutation or deletion in the gene encoding aspartate ammonium lyase (aspA). This mutation results in the loss of aspA enzymatic activity in the microorganism
Claims11
A process for the preparation of an L-amino acid selected from the group consisting of L-lysine, L-valine, L-homoserine and L-threonine, comprising:
- culturing a recombinant microorganism of the genus Escherichia for a time and under conditions suitable for the production of said L-amino acid, wherein:
- said recombinant microorganism has a deletion or mutation of the gene encoding aspartate animonium lyase (aspA) and having the amino acid sequence of SEQ ID NO:2;
- and wherein said deletion or mutation results in the elimination of aspA enzymatic activity in said microorganism.
Dependencies are inferred from the claim text.