Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor

A method for identifying a compound which modulates the activity of a polypeptide selected from the group consisting of:

• i) a polypeptide which is encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 95% identical to a nucleic acid comprising the nucleotide sequences of SEQ ID NO:14 or SEQ ID NO:16, wherein the polypeptide has aminitansferase activity;
• ii) a polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:15, wherein the variant is encoded by a nucleic acid molecule which hybridizes to a nucleic acid molecule comprising SEQ ID NO:14 or SEQ ID NO:16, or the complement thereof under conditions of 0.5M sodium phosphate, 7% SDS at 65° C., followed by one or more washes at 0.2×SSC, 1% SDS at 65° C., wherein the variant has aminotransferase activity;
• iii) a polypeptide comprising a fragment of the amino acid sequence of SEQ ID NO:15, wherein the fragment comprises at least 200 contiguous amino acids of SEQ ID NO:15, wherein the fragment has aminotransferase activity;
• and
• iv) a polypeptide comprising an amino acid sequence at least 95% identical to SEQ ID NO:15, wherein the polypeptide has aminotransferase activity;
• comprising:
• a) contacting the polypeptide or a cell comprising the polyprptide with a test compound;
• and
• b) determining the effect of the test compound on the activity of the polypeptide to thereby identify a compound which modulates the activity of the polypeptide.

A polypeptide comprising an amino acid sequence selected from the group consisting of:

• a) SEQ ID NO:
• 15
• b) the amino acid sequence encoded by SEQ ID NO:
• 14;
• and
• c) the amino acid sequence encoded by SEQ ID NO:
• 16.