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US 7,256,003 B2Granted
Method for differentiation of Alzheimer's Disease into subgroups
AssigneeThe Research Foundation for Mental Hygiene, Inc.
InventorsKhalid Iqbal, Michael Flory, Inge Grundke-Ighal
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Abstract
A method for diagnosing distinct subgroups of Alzheimer's Disease, the method comprising the steps of obtaining a sample of cerebrospinal fluid and determining the level of ubiquitin, the level of Aβ1-42, and the level of tau present in the sample. Based on the levels of each composition in the cerebrospinal fluid, the sample can be assigned to distinct subgroups.
Claims4
A method for diagnosing a distinct subgroup of Alzheimer's Disease, the method comprising the steps:
- (1) obtaining a sample of cerebrospinal fluid;
- (2) determining whether the level of ubiquitin is equal to or greater than 500 ng/ml wherein a level equal to or greater than 500 ng/ml assigns said sample to a first subgroup, if not then;
- (3) determining whether the level of Aβ 1-42 is equal to or greater than 900 pg/ml and if so assigning to a second subgroup, if not then;
- (4) determining whether the level of tau is equal to or greater than 920 pg/ml and if so, assigning said sample to a third subgroup, if not then;
- (5) determining whether the level of tau is equal to or greater than 520 pg/ml and if so, assigning said sample to a fourth subgroup, if not then assigning said sample to a fifth subgroup.
2 more elements
Dependencies are inferred from the claim text.