Evaluation and preservation solution
AssigneeVitrolife AB
InventorStig Steen
Life of this patent
Estimating the term…
Abstract
An evaluation and preservation solution for human and animal organs, tissues and parts thereof is described, wherein it comprises serum albumin at a concentration of 55-105 g/L, a scavenger and coating compound, preferably dextran compounds and derivatives thereof having essentially the same structure at a concentration of 1-55 g/L weight, and a physiological serum concentration of salts and nutrients in a physiologically acceptable medium.
Claims38
An evaluation and preservation solution for human and animal organs, tissues and parts thereof, comprising (a) serum albumin at a concentration of 55-105 g/L, (b) a dextran compound which coats the capillary endothelium of the organs, tissues or parts thereof at a concentration of 1-55 g/L, said dextran compound comprising dextran molecules (c) a physiological serum concentration of salts, and (d) nutrients for the organs, tissues or parts thereof, in a physiologically acceptable medium, and provides an oncotic pressure higher than an applied hydrostatic pressure in the organs, tissues or parts thereof, and wherein the solution prevents oedema formation.
A ready to use, mixed evaluation and preservation solution for human and animal organs, tissues and parts thereof comprising:
- red blood cells with an erythrocyte volume fraction of 15%±5%, serum albumin at a concentration of 50-100 g/L, and a dextran compound at a concentration of 1-50 g/L.
An evaluation and preservation solution for human and animal organs, tissues and parts thereof, comprising (a) serum albumin at a concentration of 70 g/L, (b) a dextran compound which coats the capillary endothelium of the organ, tissues or parts thereof at a concentration of 5 g/L, said dextran compound comprising dextran molecules having molecular weights ranging from 1 to 250 kDa (c) a physiological serum concentration of salts, and (d) nutrients for the organs, tissues and parts thereof, in a physiologically acceptable medium.
Dependencies are inferred from the claim text.