Integrin targeted imaging agents
AssigneesBarnes-Jewish Hospital, Bristol-Myers Squibb Medical Imaging, Inc.
InventorsGregory M. Lanza, Samuel A. Wickline, Tom Harris
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Abstract
Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated endothelial cells by coupling said nanoparticles to a ligand specific for αvβ3 integrin, other than an antibody. The nanoparticles may further include biologically active agents, radionuclides, or other imaging agents.
Claims9
A method to deliver an emulsion comprising nanoparticles to a target tissue, wherein said target tissue is characterized by high levels of αvβ3integrin,
- which method comprises administering to a subject comprising such tissue an emulsion of nanoparticles wherein said nanoparticles are coupled to a ligand specific for αvβ3integrin,
- wherein said nanoparticles consist of liquid perfluorocarbon cores coated with lipid/surfactant, and wherein the coupling of said nanoparticles to the ligand is through a covalent linkage, through a spacer, to a component of the lipid/surfactant coating, and
- wherein the ligand comprises a residue of the formula
Dependencies are inferred from the claim text.