Group A streptococcal vaccines
AssigneeUniversity of Tennessee Research Foundation
InventorJames B Dale
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for eliciting an immune response against Group A streptococci, comprising use of recombinant fusion polypeptides, and compositions thereof, that include a multivalent immunogenic portion of at least two immunogenic polypeptides from Group A streptococci M proteins (which are capable of stimulating a protective immune response against Group A streptococci), and a reiterated polypeptide from the immunogenic portion carboxy-terminal to the immunogenic portion, wherein the carboxy-terminal polypeptide is not required to stimulate an immune response against Group A streptococci.
Claims26
A method for eliciting an immune response against Group A streptococci comprising administering to a patient a pharmaceutical composition comprising (a) a recombinant fusion polypeptide wherein said recombinant fusion polypeptide comprises a multivalent immunogenic portion fused to an immunogenic polypeptide carboxy-terminal to the multivalent immunogenic portion, which protects the immunogenicity of the multivalent immunogenic portion, wherein the multivalent immunogenic portion comprises at least two immunogenic amino-terminal polypeptides of Group A streptococcal M protein from at least two different Group A streptococcal serotypes, wherein the immunogenic polypeptide carboxy-terminal to the multivalent immunogenic portion is a reiteration of the immunogenic amino-terminal polypeptide from the amino terminus of the multivalent immunogenic portion, and wherein each of the at least two immunogenic amino-terminal polypeptides is at least 10 amino acids in length, and (b) a pharmaceutically acceptable excipient, carrier, stabilizer or diluent, thereby eliciting said immune response against said Group A streptococci.
Dependencies are inferred from the claim text.