Lysyl oxidase-like 1 (LOXL1) and elastogenesis
AssigneeMassachusetts Eye and Ear Infirmary
InventorsTiansen Li, Xiaoqing Liu
Life of this patent
Estimating the term…
Abstract
Described are methods of treating and preventing conditions associated with a loss of elastic fibers. Also provided herein are methods of screening for agents useful in treating such conditions, and animal models of conditions associated with a loss of elastic fibers.
Claims30
A method of treating a subject having pelvic organ prolapse or urinary incontinence, wherein the pelvic organ prolapse or urinary incontinence is associated with a loss of elastic fibers, the method comprising administering to the subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to amino acids 26–574 of SEQ ID NO:
- 13 and can catalyze crosslinking of tropoelastin to form elastin.
A method of preventing the development or progression of pelvic organ prolapse or urinary incontinence in a subject, wherein the subject has pelvic organ prolapse or urinary incontinence associated with a loss of elastic fibers, the method comprising administering to a subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to amino acids 26–574 SEQ ID NO:
- 13 and can catalyze crosslinking of tropoelastin to form elastin.
A method of treating a subject having pelvic organ prolapse or urinary incontinence, wherein the pelvic organ prolapse or urinary incontinence is associated with a loss of elastic fibers, the method comprising administering to the subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to amino acids 26-607 of SEQ ID NO:
- 14 and can catalyze crosslinking of tropoelastin to form elastin.
A method of treating a subject having pelvic organ prolapse or urinary incontinence, wherein the pelvic organ prolapse or urinary incontinence is associated with a loss of elastic fibers, the method comprising administering to the subject a therapeutically effective amount of a Lysyl Oxidase-Like-l (LOXL1) polypeptide that is at least 95% identical to SEQ ID NO:
- 15 and can catalyze crosslinking of tropoelastin to form elastin.
A method of treating a subject having pelvic organ prolapse or urinary incontinence, wherein the pelvic organ prolapse or urinary incontinence is associated with a loss of elastic fibers, the method comprising administering to the subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to SEQ ID NO:
- 16 and can catalyze crosslinking of tropoelastin to form elastin.
A method of preventing the development or progression of pelvic organ prolapse or urinary incontinence in a subject, wherein the subject has pelvic organ prolapse or urinary incontinence associated with a loss of elastic fibers, the method comprising administering to a subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to amino acids 26-607 of SEQ ID NO:14 and can catalyze crosslinking of tropoelastin to form elastin.
A method of preventing the development or progression of pelvic organ prolapse or urinary incontinence in a subject, wherein the subject has pelvic organ prolapse or urinary incontinence associated with a loss of elastic fibers, the method comprising administering to a subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to SEQ ID NO:
- 15 and can catalyze crosslinking of tropoelastin to form elastin.
A method of preventing the development or progression of pelvic organ prolapse or urinary incontinence in a subject, wherein the subject has pelvic organ prolapse or urinary incontinence associated with a loss of elastic fibers, the method comprising administering to a subject a therapeutically effective amount of a Lysyl Oxidase-Like-1 (LOXL1) polypeptide that is at least 95% identical to SEQ ID NO:
- 16 and can catalyze crosslinking of tropoelastin to form elastin.
Dependencies are inferred from the claim text.