Use of lymphotoxin-β receptor blocking agents for the treatment of antibody mediated immunological diseases
AssigneeBiogen, Inc.
InventorsJeffrey L. Browning, Paula S. Hochman, Paul D. Rennert, Fabienne Mackay
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Abstract
Compositions and methods comprising “lymphotoxin-β receptor blocking agents” which block lymphotoxin-β receptor signaling and are useful for altering immunological diseases, and particularly antibody mediated immune responses.
Claims35
A method for inhibiting a humoral immune response in a human comprising administering to the human mammal a pharmaceutical composition comprising an effective amount of a soluble human lymphotoxin-beta receptor (LTβR) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and a pharmaceutically acceptable carrier, such that a humoral immune response is inhibited.
A method for inhibiting a humoral immune response by inhibiting LT-β receptor signaling without inhibiting TNF-R signaling in a human subject comprising administering to a human subject a pharmaceutical composition comprising an amount of a soluble human lymphotoxin-β receptor (LTβR) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and a pharmaceutically acceptable carrier, such that a humoral immune response is inhibited by inhibiting human LT-β receptor signaling without inhibiting TNF-R signaling.
A method for disrupting the association of immune complexes and B cell follicles in a human subject comprising administering to the human subject a pharmaceutical composition comprising an amount of a soluble human lymphotoxin-βreceptor (LTβR) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and pharmaceutically acceptable carrier, such that the association of immune complexes and B cell follicles is disrupted.
A method of treating an antibody-mediated autoimmune disorder in a human subject suffering from an autoimmune disorder, comprising administering to the human subject a pharmaceutical composition comprising an effective amount of a soluble human lymphotoxin-β receptor (LTβ R) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and a pharmaceutically acceptable carrier, such that the antibody-mediated autoimmune disorder is treated.
A method of inhibiting a humoral response in a human subject suffering from a hypersensitivity response, comprising administering to the human subject a pharmaceutical composition comprising an effective amount of a soluble human lymphotoxin-β receptor (LTβR) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and a pharmaceutically acceptable carrier, such that a humoral response is inhibited.
A method of inhibiting a humoral response associated with graft rejection in a human subject comprising administering a pharmaceutical composition comprising an effective amount of a soluble human lymphotoxin-β receptor (LTβR) fused to one or more heterologous protein domains, wherein the soluble human LTβR comprises at least one ligand binding domain that can selectively bind to a human surface LT ligand, and a pharmaceutically acceptable carrier, such that the humoral immune response associated with graft rejection is inhibited.
A method for inhibiting a humoral immune response in a human comprising administering a pharmaceutical composition comprising a soluble human lymphotoxin-beta receptor (LTβR) comprising SEQ ID NO:
- 1 fused to a human IgG1 Fc domain and a pharmaceutically acceptable carrier, such that the humoral immune response is inhibited.
A method for inhibiting a humoral immune response by inhibiting LT-β receptor signaling without inhibiting TNF-R signaling in a human comprising administering a pharmaceutical composition comprising a soluble human lymphotoxin-beta receptor (LTβR) comprising SEQ ID NO:
- 1 fused to a human IgG1 Fc domain and a pharmaceutically acceptable carrier, such that the humoral immune response is inhibited by inhibiting human LT-β receptor signaling without inhibiting TNF-R signaling.
A method for disrupting the association of immune complexes and B cell follicles in a human comprising administering a pharmaceutical composition comprising a soluble human lymphotoxin-beta receptor (LTβR) comprising SEQ ID NO:
- 1 fused to a human IgG1 Fc domain and a pharmaceutically acceptable carrier, such that the association of immune complexes and B cell follicles is disrupted.
Dependencies are inferred from the claim text.