Non-invasive localization of a light-emitting conjugate in a mammal
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsPamela R. Contag, Christopher H. Contag, David A. Benaron
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Abstract
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
Claims17
A non-invasive method for detecting a biocompatible entity under study from within a mammalian subject, comprising:
- administering to the mammalian subject a conjugate of the biocompatible entity and a light-generating moiety;
- and
- measuring photon emission through an opaque tissue of said mammalian subject from the light-generating moiety.
Dependencies are inferred from the claim text.