Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers
AssigneeSami Labs Limited
InventorsMuhammed Majeed, Samuel Manoharan Thomas, Kalyanam Nagabhushanam, Sivaprakash Kurumanghat Balakrishnan, Subbalakshmi Prakash
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Abstract
Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
Claims7
A process of preparing phenolic product by aromatic O-dealkylation consisting of treating alkoxy-aromatic compound with aluminum salt-amine reagent up to temperature of 120° C. optionally in a solvent for up to 8 hrs, hydrolyzing the reaction mixture with water, acidification and extraction of the phenolic product.
Dependencies are inferred from the claim text.