Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles

A compound of formula I-C:

• wherein
• R12, R13 and R14 are independently hydrogen, halogen, trifluoromethyl, lower alkyl, lower alkoxy lower alkyl, lower alkoxy lower alkoxy lower alkyl, halo lower alkoxy, lower alkyl aminocarbonyl or di-lower alkyl aminocarbonyl, cyano;
• R26 is (CH2)n—Y, hydroxy lower alkyl, lower alkoxycarbonyl lower alkyl or carbamoyl lower alkyl;
• R27 is hydrogen or lower alkyl;
• Y is oxazolidinone, cyclobutanonyl, [1,2,4]triazol-3-yl, [1,2,4]oxadiazol-3-yl, [1,2,4]triazol-3-one-5-yl, tetrazolyl, [1,3,4]oxadiazol-2-yl, [1,3,4]thiadiazol-2-yl, 1H-imidazol-2-yl or 1H-imidazol-4-yl;
• and
• n is 0, 1, 2 or 3.