Complementarity determining region-grafted antibody against ganglioside GD3 and derivative of antibody against ganglioside GD3
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsNobuo Hanai, Kenya Shitara, Kazuyasu Nakamura, Rinpel Niwa
Life of this patent
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Abstract
The present invention relates to a human CDR-grafted antibody against ganlioside GD3 (hereinafter referred to “GD3”), derivatives of an anti-GD3 antibody and cytokine, and use for treatment and diagnosis of the antibody and the derivatives.
Claims12
An antibody conjugate, comprising a humanized antibody or an antibody fragment thereof which is conjugated with a therapeutic agent, wherein the humanized antibody or the antibody fragment thereof specifically binds to ganglioside GD3 and comprises:
- the H chain V region having the amino acid sequence of SEQ ID NO:9;
- and
- the L chain V region having the amino acid sequence of SEQ ID NO:54.
An antibody conjugate, comprising a humanized antibody produced by the transformant KM8871 (FERM BP-6790) or an antibody fragment thereof which is conjugated with a therapeutic agent, wherein the humanized antibody or the antibody fragment thereof specifically binds to ganglioside GD3.
An antibody conjugate, comprising a humanized antibody or an antibody fragment thereof which is conjugated with a therapeutic agent, wherein the humanized antibody or the antibody fragment thereof specifically binds to ganglioside GD3, the humanized antibody is produced by transformant KM8871 (FERM BP-6790) and the therapeutic agent is hIL-2.
An antibody conjugate, comprising a humanized-antibody or an antibody fragment thereof which is conjugated with hIL-2,
- wherein the humanized antibody or the antibody fragment thereof specifically binds to ganglioside GD3 and comprises:
- the H chain V region having the amino acid sequence of SEQ ID NO:9;
- and
- the L chain V region having the amino acid sequence of SEQ ID NO:54,
- wherein the H chain V region conjugated with hIL-2 has the amino acid sequence of SEQ ID NO:53.
A humanized antibody or an antibody fragment thereof which specifically binds to ganglioside GD3 and comprises:
- the H chain V region having the amino acid sequence of SEQ ID NO:9;
- and
- the L chain V region having the amino acid sequence of SEQ ID NO:10 in which at least one or more amino acid residue selected from 41st position Gly, 44th position Pro, 83rd position Phe and 87th position Tyr is replaced with Asp, Val, IIe and Phe, respectively.
Dependencies are inferred from the claim text.