Phenyl derivatives comprising an acetylene group

A compound of the formula I

• wherein:
• X1 is O or S;
• R1 is hydrogen or C1-7-alkyl;
• R2 is hydrogen or C1-7-alkyl,
• R3 is hydrogen or C1-7-alkyl;
• R4 and R8 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7alkyl, fluoro-C1-7-alkoxy, cyano-C1-7-alkyl and cyano;
• R5, R6 and R7 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl, fluoro-C1-7-alkoxy, cyano-C1-7-alkyl and cyano;
• and one of R5, R6 and R7 is
• wherein
• X2 is selected from the group consisting of
• S, O, NR9, (CH2)PNR9CO and (CH2)PCONR9;
• R9 is selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl, hydroxy-C2-7-alkyl and C1-7-alkoxy-C2-7-alkyl;
• R10 is selected from the group consisting of C1-7-alkyl, C3-7-cycloalkyl, fluoro-C1-7-alkyl and C1-7-alkoxy-C1-7-alkyl;
• R11 is selected from the group consisting of hydrogen, C1-7-alkyl, and C1-7-alkoxy-C1-7-alkyl;
• or R10 and R11 together with the carbon atom they are attached to form a C3-6-cycloalkyl ring;
• m, o, p is 0, 1 or 2;
• n is 0, 1, 2 or 3;
• and the sum of m, n and o is 1 to 5;
• R12 is unsubstituted phenyl, phenyl substituted with one to three groups selected from the group consisting of C1-7-alkyl, C1-7-alkoxy, halogen, fluoro-C1-7-alkyl, fluoro-C1-7-alkoxy and cyano, unsubstituted pyridyl or pyridyl substituted with one to three groups selected from the group consisting of C1-7-alkyl, C1-7-alkoxy, halogen, fluoro-C1-7-alkyl, fluoro-C1-7-alkoxy and cyano;
• and pharmaceutically acceptable salts or esters thereof.