Aminobenzamide derivative
AssigneeBanyu Pharmaceutical Co., Ltd.
InventorsTeruyuki Nishimura, Tomoharu Iino, Yasufumi Nagata, Jun-ichi Eiki
Life of this patent
Estimating the term…
Loading patent…
AssigneeBanyu Pharmaceutical Co., Ltd.
InventorsTeruyuki Nishimura, Tomoharu Iino, Yasufumi Nagata, Jun-ichi Eiki
Estimating the term…
This invention relates to a novel compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p and q, which are the same or different, each represent an integer from 0 to 2, A is a straight chain C1-C10 alkyl group which may be substituted by R10, and B and D each independently represent R12 which may be substituted by R10; R2 is a hydrogen atom, a halogen atom, or a straight chain or branched C1-C6 alkyl group which may be substituted by R10; X1 and X2 each independently represent N or CH, but cannot both be N; the formula (II): shows a monocyclic or bicyclic heteroaryl group which has a nitrogen atom adjacent to the carbon atom bonded to the amide group, and the heteroaryl group may be substituted by R10; R10 is R11, or a hydrocarbon group which may be substituted by R11; R11 is, for example, a hydrogen atom or amino; and R12 is, for example, phenyl, thiazolyl, pyridyl or methylene dioxyphenyl. The compound according to this invention has a glucokinase activation effect, and for example, is useful in the treatment and prevention of diabetes mellitus, and in the prevention of its complications such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and diabetic arteriosclerosis.
A compound represented by the formula (I):
Dependencies are inferred from the claim text.