Fused heterocyclic compounds

A compound having the formula (I):

• or a pharmaceutically acceptable salt, thereof, wherein
• represents a single or fused aryl or heteroaryl ring;
• Q is —N(R) (C1)alkylene-;
• R is
• L1 is a bond, (C1-C4)alkylene, (C1-C4)alkylenoxy and (C1-C4)alkylenamino;
• L2 is a bond, (C1-C4)alkylene, (C2-C4)alkenylene, (C2-C4)alkynylene, (C1-C4)alkylenoxy (e.g. —OCH2CH2—) or (C1-C4)alkylenamino (e.g. —NH—CH2CH2—);
• R″ is hydrogen or (C1-C8)alkyl;
• each R1 is independently selected from the group consisting of halogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, fluoro(C1-C4)alkyl, —OR5, —SR5, fluoro(C1-C4)alkoxy, aryl, aryl(C1-C4)alkyl, —NO2, —NR5R6, —C(O)R5, —CO2R5, —C(O)NR5R6, —N(R6)C(O)R5, —N(R6)CO2R5, —N(R7)C(O)NR5R6, —S(O)mNR5R6, —S(O)mR5, —CN and —N(R6)S(O)mR5;
• R2 and R3 are independently selected from the group consisting of hydrogen, halogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, fluoro(C1-C4)alkyl, —OR8, —SR8, fluoro(C1-C4)alkoxy, aryl, aryl(C1-C4)alkyl, —NO2, —NR8R9, ═O, —C(O)R8, —CO2R8, —C(O)NR8R9, —N(R9)C(O)R8, —N(R9)CO2R8, —N(R10)C(O)NR8R9, —S(O)mNR8R9, —S(O)mR8, —CN and —N(R9)S(O)mR8;
• R4 is selected from the group consisting of hydrogen, —OR11, —C(O)R11, —CO2R11, —C(O)NR11R12, —CN, (C1-C4)alkyl and aryl;
• X and Y are independently selected from the group consisting of (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, —CO2R13 and —C(O)NR13R14;
• optionally, X and Y may be combined to form a 3-, 4-, 5-, 6- or 7-membered ring containing from 0 to 2 heteroatoms independently selected from the group consisting of N, O and S;
• Z is selected from the group consisting of —OR15, —NR15R16, —NR15R18, —C(O)R15, —CO2R15, —R18, —C(O)NR15R16, —C(O)NR15R18, —SO2NR15R16, —SO2NR15R18, —NR16SO2R15, —N(R15)N(R16)SO2R17, —C(O)N(R16)OR15, hydroxy(C1-C8)alkyl, fluoro(C1-C4)alkyl, heteroaryl, —C(═NOR15)NR16R17, —C(R16))═NOR15, —NR16(OR15), —C(O)NR17C(O)NR15R16, —NR17C(O)NR16C(O)R15 and —NR17C(O)NR15R16;
• R5, R6, R7, R8,R9, R10, R11, R12, R13, R14, R15, R16 and R17 are independently selected from the group consisting of hydrogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, cyclo(C3-C6)alkyl, fluoro(C1-C4)alkyl, hetero(C1-C4)alkyl, cyclohetero(C3-C6)alkyl, aryl and aryl(C1-C4)alkyl;
• R18 is a 5- or 6-membered ring containing from 0 to 4 heteroatoms selected from the group consisting of N, O and S;
• optionally, when two variables selected from the group of variables consisting of R5, R6, R8, R9, R11, R12, R13, R14, R15, R16 and R17 are attached to the same nitrogen atom, the two variables may be combined to form a 3-, 4-, 5-, 6- or 7-membered ring containing the nitrogen atom and from 0 to 2 additional heteroatoms selected from the group consisting of N, O and S;
• the subscript m is 1 or 2;
• and
• the subscript n is 0, 1 or 2.