Immunosuppressive effects of 8-substituted xanthine derivatives

An immunosuppressive composition in unit dosage form for immunosuppression incident to organ transplantation and xenogenic events comprising:

• a) a first immunosuppressive compound having general Formula (I), as follows:
• wherein R1, R2 and R3 are independently hydrogen, saturated or unsaturated, straight or branched C1-6 aliphatic chains,
• X and Y are independently oxygen or sulfur,
• Z1 is selected from the group consisting of an unsubstituted thienyl group and an unsubstituted furanyl group, and
• Z2 is selected from the group consisting of a phenyl group;
• a sulfonic acid group;
• an unsubstituted sulfonamide group;
• a substituted sulfonamide group that is substituted with one of an alkyl group, an unsubstituted aminoalkyl group and a C1-4 alkyl-substituted aminoalkyl group;
• an amino group;
• a halogen-substituted amino group;
• a C1-3 aliphatic group;
• a halogen-substituted C1-3 aliphatic group and a C1-12 aliphatic group that is substituted with one or more functional groups selected from the group consisting of an ester group, an amide group, an unsubstituted amine group, a C1-3 alkyl-substituted amine group and a sulfonamide group,
• or a pharmaceutically acceptable salt thereof in an amount effective to cause immunosuppression in a patient;
• and
• b) a pharmaceutically acceptable excipient.