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US 7,253,174 B2Granted
N-heterocyclic inhibitors of TNF-α expression
AssigneesBristol-Myers Squibb Company, Pharmacopeia, Inc.
InventorsGulzar Ahmed, Axel Metzger, Ian Henderson, David J. Diller, Jun Wen, Stephen T. Wrobleski, Katerina Leftheris, Chunjian Liu
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Abstract
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I): Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
Claims8
A compound of Formula (I),
- or enantiomers, diastereomers, tautomers, and pharmaceutically acceptable salts thereof,
- wherein:
- Y and X are ═N—;
- is selected from ═C—CN, ═C—F, ═C—Br, ═C—NH2, ═C—NHC(O)CH3 and ═C—Cl;
- V is —NR5—;
- Z is halogen or —N(R1)(R2);
- R1 and R2 are the same or different and are selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, saturated heterocyclyl or substituted saturated heterocyclyl;
- R5 is hydrogen or alkyl;
- R6 is
- R7 is alkyl, substituted alkyl, alkoxy, or halogen;
- R8 is hydrogen, alkyl, alkyloxy or cyano;
- R9 is —C(O)R10 or unsubstituted or substituted heterocyclyl;
- R10 is —N(R31)(R32);
- R31 and R32 are the same or different and are selected from hydrogen, alkyl, substituted alkyl, alkoxy, aryl, substituted aryl, cycloalkyl, substituted cycloalkyl, heterocyclyl or substituted heterocyclyl;
- and
- R11 is hydrogen or halogen.
13 more elements
Dependencies are inferred from the claim text.