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AssigneesIrm LLC, The Scripps Research Institute
InventorsSheng Ding, Tom Wu, Nathanael S. Gray, Peter Schultz
Estimating the term…
The invention provides a novel class of compounds and compositions of Formula I: in which R1, R2 and R3 are defined herein, that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK-3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to the use of the compounds of the invention as potent inducers of neurogenesis in embryonic stem cells.
A compound of Formula I:
Dependencies are inferred from the claim text.
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From the US filing history. Foreign family members aren’t listed.
In which the condensed system contains two hetero rings: ortho-condensed systems
Drugs for disorders of the nervous system: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents,…
Heterocyclic compounds
Therapeutic uses of medicines
Term ended 22 Apr 2024 (estimated)
1. Field of the Invention
The invention provides a novel class of compounds and compositions that are useful in the treatment or prevention of diseases or disorders associated with kinases, particularly GSK3β, c-Abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and c-Met kinases. The invention further relates to a method of using compounds of the invention to induce neurogenesis in embryonic stem cells.
2. Background
The invention provides compounds that are useful in the treatment and/or prevention of diseases or disorders mediated by the cell signaling pathways in which GSK-3β, c-Abl, Bcr-abl, HER-1, HER-2, KDR, Flt-3, c-Raf-1, PDGFR-β, c-Kit, Flt-4, Flt-1, Tek, c-src, CDK1, PDK1, FGFR-1, FGFR-2, Fer, MAP3K13, EPHA7 and/or c-Met play a role. Also provided are methods for treating such diseases or disorders.
In this specification, unless otherwise defined:
“Alkyl” as a group and as a structural element of other groups, for example halo-substituted-alkyl and alkoxy, can be either straight-chained or branched.