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US 7,253,161 B2Granted
Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same
AssigneeLes Laboratoires Servier
InventorsAlex Cordi, Patrice Desos, Pierre Lestage
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts. Medicaments.
Claims12
A compound selected from those of formula (I):
- wherein:
- R1 represents aryl or heteroaryl,
- R2 represents hydrogen, halogen or hydroxy,
- A represents NR4, and R3 and R4, together with the carbon and nitrogen atoms to which they are attached, form a ring
- wherein m represents 1, 2 or 3,
- its isomers and addition salts thereof with a pharmaceutically acceptable acid or base,
- it being understood that:
- “aryl” may be an aromatic monocyclic group or a bicyclic group in which at least one of the rings is aromatic, each of those groups being optionally substituted by one or more identical or different halogen, linear or branched (C1-C6)alkyl (optionally substituted by one or more hydroxy groups), linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)alkoxycarbonyl, linear or branched (C1-C6)alkylthio, carboxy, linear or branched (C1-C6)acyl, linear or branched (C1-C6)perhaloalkoxy, hydroxy, cyano, nitro, amino (optionally substituted by one or more linear or branched (C1-C6)alkyl or linear or branched (C1-C6)acyl), aminocarbonyl (optionally substituted by one or more linear or branched (C1-C6)alkyl), aminosulphonyl (optionally substituted by one or more linear or branched (C1-C6)alkyl), mono- or di-((C1-C6)alkylsulphonyl)amino, mono- or di-(trifluoromethylsulphonyl)amino, PO(ORa)(ORb) (wherein Ra, Rb, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl), benzyloxy, or phenyl (optionally substituted by one or more identical or different halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, hydroxy or linear or branched (C1-C6)alkoxy),
- “heteroaryl” may be an aromatic monocyclic group, or a bicyclic group in which at least one of the rings is aromatic, containing one, two or three identical or different hetero atoms selected from nitrogen, oxygen and sulphur, each of those groups being optionally substituted by one or more identical or different halogen, linear or branched (C1-C6)alkyl, linear or branched (C1-C6)alkoxy, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)alkoxycarbonyl, carboxy, linear or branched (C1-C6)acyl, linear or branched (C1-C6)perhaloalkoxy, hydroxy, cyano, nitro, amino (optionally substituted by one or more linear or branched (C1-C6)alkyl), aminosulphonyl (optionally substituted by one or more linear or branched (C1-C6)alkyl), or (C1-C6)-alkylsulphonylamino.
6 more elements
Dependencies are inferred from the claim text.