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US 7,253,159 B2Granted
Methods and compositions for immunomodulation using CD1 antigens
AssigneesThe Brigham and Women's Hospital, Inc., Trustees of Boston University
InventorsD. Branch Moody, David C. Young, Catherine E. Costello
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Abstract
The invention relates to novel CD1a-presented antigens. These antigens can be used as antigens, adjuvants or as immunomodulatory agents in a variety of diagnostic, therapeutic and prophylactic applications.
Claims32
An isolated compound of Formula 1, wherein Formula I is
- wherein R is an alkyl chain or an alkene chain.
An isolated compound of Formula IV, wherein Formula IV is
- wherein R is an alkyl chain or an alkene chain.
A method for isolating a compound of Formula I wherein Formula I is
- wherein R is of an alkyl chain or an alkene chain, comprising
- performing a cold acetone precipitation of a mycobacterial sample to form a precipitate,
- dissolving the precipitate in chloroform,
- eluting the dissolved precipitate through a silica gel in a methanol solvent, and
- performing a reversed phase HPLC using C8 matrix.
2 more elements
A method for isolating a compound of Formula IV wherein Formula IV is
- wherein R is an alkyl chain or an alkene chain, comprising
- wherein R is an alkyl chain or an alkene chain.
Dependencies are inferred from the claim text.