Combinations for the treatment of immunoinflammatory disorders
AssigneeCombinatoRx, Incorporated
InventorsCurtis Keith, Alexis Borisy, Grant Zimmerman, Edward Roydon Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael A. Foley
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Abstract
The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.
Claims54
A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising administering to said patient:
- (a) a corticosteroid;
- and
- (b) dipyridamole, wherein said dipyridamole and said corticosteroid are administered simultaneously or within one hour of each other, in amounts and for a duration sufficient to treat said patient, and wherein said dipyridamole is administered orally or intravenously.
A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising orally or intravenously administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.
A method for treating a patient who has rheumatoid arthritis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.
A method for treating a patient who has psoriasis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.
A method for treating a patient who has ulcerative colitis, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.
A method for treating a patient who has Crohn's disease, said method comprising orally administering to said patient a composition comprising dipyridamole and a corticosteroid in an amount and for a duration sufficient to treat said patient.
A method for treating a patient who has an immunoinflammatory disorder selected from rheumatoid arthritis, psoriasis, ulcerative colitis, Crohn's disease, ankylosing spondylitis, or multiple sclerosis, said method comprising orally or intravenously administering to said patient a composition consisting of active ingredients and excipients, wherein said active ingredients consist of a corticosteroid and dipyridamole, in an amount and for a duration sufficient to treat said patient.
Dependencies are inferred from the claim text.