Peptides based on the sequence of human lactoferrin and their use
AssigneePharmaSurgics in Sweden AB
InventorsLars {dot over (A)}. Hanson, Lars Baltzer, Inger Mattsby-Baltzer, Gunnar T. Dolphin
Life of this patent
Estimating the term…
Abstract
The invention relates to new peptides formed of at least seven subsequent amino acids of the amino acids in position 12-40, counted from the N-terminal end, in the sequence constituting human lactoferrin, and preferably modifications thereof. The invention also relates to medicinal products comprising such peptides, especially intended for treatment and prevention of infections, inflammations and tumours. Furthermore, the invention relates to food stuff, e.g. infant formula food, comprising the above mentioned peptides.
Claims34
A purified peptide comprising 20Cys-Phe-X1-X2-X3-X4-X5-X6-X7-Lys-Val-Arg31 (SEQ ID NO:
- 99) wherein X1 is Gln, or Ala;
- X2 is Trp or Leu;
- X3 is Gln, Lys, Orn, Ala, or Nle;
- X4 is Arg, Lys, Ala;
- X5 is Asn, Orn, Ala, or Nle;
- X6 is Met or Leu;
- and X7 is Arg or Lys, and wherein the peptide is SEQ ID NO:2-5, 8, 31-37, 47, 49, 51, 63, 65, 67, 70, 72-74, 80-83, 87-96 or 97.
A purified peptide comprising 20Cys-Phe-X1-X2-X3-X4-X5-X6-X7-Lys-Val-Arg31 (SEQ ID NO:
- 99) wherein X1 is Gln, or Ala;
- X2 is Trp or Leu;
- X3 is Gln, Lys, Orn, Ala, or Nle;
- X4 is Arg, Lys, Ala;
- X5 is Asn, Orn, Ala, or Nle;
- X6 is Met or Leu;
- and X7 is Arg or Lys, wherein the peptide is SEQ ID NO:2-5, 8, 31-37, 47, 49, 51, 63, 65, 67, 70, 72-74, 80-83, 87-88 or 89, and wherein the cysteine is replaced by an acetamidomethyl-cysteine.
A purified peptide, comprising 20Cys-Phe-X1-X2-X3-X4-X5X6-X7-Lys-Val-Arg31 (SEQ ID NO:
- 99), wherein
- X1 is Gln or Ala;
- X2 is Trp or Leu;
- X3 is Gln, Lys, Orn, Ala, or Nle;
- X4 is Arg, Lys, or Ala;
- X5 is Asn, Orn, Ala, or Nle;
- X6 is Met or Leu;
- X7 is Arg or Lys;
- wherein the peptide is the amino acid sequence consisting of TK or EATK (SEQ ID NO:102) at the amino acid terminus of the peptide of SEQ ID NO:70, 72, 73, 74, 80-83, 87-91, 93-95, or 97.
Dependencies are inferred from the claim text.