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US 7,253,008 B2Granted
Reactive ion etched substrates and methods of making and using
AssigneeSandia Corporation
InventorsVictor C. Rucker, Renée Shediac, Blake A. Simmons, Karen L. Havenstrite
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Abstract
Disclosed herein are substrates comprising reactive ion etched surfaces and specific binding agents immobilized thereon. The substrates may be used in methods and devices for assaying or isolating analytes in a sample. Also disclosed are methods of making the reactive ion etched surfaces.
Claims13
A substrate comprising
- at least one reactive ion etched polymethylmethacrylate or cyclo-olefin surface having at least one polypeptide bound directly thereon;
- at least one unetched polymethylmethacrylate or cyclo-olefin surface which fails to bind the polypeptide directly thereon when contacted therewith;
- and
- at least one reactive ion etched or unetched surface of a second polymer wherein the reactive ion etched surface of the second polymer fails to bind the polypeptide directly thereon when contacted therewith;
- wherein the polypeptide specifically binds a ligand of interest in a sample to be assayed;
- and wherein said binding directly thereon is in the absence of a linker.
3 more elements
Dependencies are inferred from the claim text.