Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors
AssigneeChemoCentryx, Inc.
InventorsJennifer M. Burns, Bretton Summers, Maureen C. Howard, Thomas J. Schall
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Abstract
Ligands of CCX-CKR2 and the biological role of CCX-CKR2 in cancer is described.
Claims14
A method of identifying an agent that binds to CCX-CKR2 on a cell, the method comprising,
- contacting a plurality of agents and a CCX-CKR2 ligand to a polypeptide comprising an extracellular domain at least 95% identical to an extracellular domain of a CCX-CKR2 polypeptide comprising SEQ ID NO:2, or a fragment of the CCX-CKR2 polypeptide that binds SDF1 or I-TAC, wherein the CCX-CKR2 ligand is SDF1 or I-TAC;
- and
- selecting an agent that competes with I-TAC or SDF1 for binding to the CCX-CKR2 polypeptide or fragment thereof, thereby identifying an agent that binds to CCX-CKR2 on a cell.
A method of competing SDF1 or I-TAC and an agent for binding to a CCX-CKR2 polypeptide, the method comprising contacting a cell with an agent that specifically binds to a polypeptide comprising SEQ ID NO:2, wherein the agent competes with SDF-1 or I-TAC for binding to the CCX-CKR2 polypeptide, and wherein the cell expresses a CCX-CKR2 polypeptide comprising an extracellular domain at least 95% identical to an extracellular domain of SEQ ID NO:2.
Dependencies are inferred from the claim text.