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US 7,253,003 B2Granted
Method for monitoring the environment within a microfluidic device
AssigneeWisconsin Alumni Research Foundation
InventorsDavid J. Beebe, Jaisree Moorthy
Life of this patent
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Abstract
A method and apparatus is provided for monitoring the environment within a microfluidic device. The microfluidic device includes a body defining a channel for accommodating flow of fluid therethrough. A monitor structure is disposed in the channel of the body in the flow of fluid. The monitor structure changes color and/or dimension in response to various parameters of the fluid having predetermined values.
Claims14
A method for monitoring the environment within a microfluidic device, comprising the steps of:
- immobilizing a first monitor structure in a channel of the microfluidic device by:
- mixing a dye in a pre-polymer mixture to provide a pregel mixture;
- injecting the pregel in the channel of the microfluidic device;
- and
- polymerizing the pregel mixture in the channel to form the first monitor structure;
- passing fluid over the monitor structure in the channel;
- providing a second monitor structure in the channel of the microfluidic device;
- and
- passing fluid over the second monitor structure in the channel;
- whereby:
- the first monitor structure generates a visual display unrelated to a potential change in the size of the first monitor structure in response to exposure to a first parameter of the fluid;
- and
- the second monitor structure generates a visual display in response to exposure to a second parameter of the fluid.
10 more elements
A method for monitoring the environment within a micro fluidic device, comprising the steps of:
- mixing a dye in a pre-polymer mixture to provide a pregel mixture;
- injecting the pregel mixture into a channel of the microfluidic device;
- polymerizing the pregel mixture in the channel to form a first monitor structure;
- passing fluid over the first monitor structure in the channel such that the dye changes color in response to a parameter of the fluid;
- and
- passing fluid over a second monitor structure provided in the channel such that the second monitor structure changes color in response to a second parameter of the fluid.
3 more elements
Dependencies are inferred from the claim text.