Structural protein of adeno-associated virus with modified antigenicity, its production and its use

A method for reducing the antigenicity, relative to wild-type AAV, of an AAV particle, the method comprising introducing at least one modification into a structural protein of AAV, the structural protein being selected from the group consisting of AAV VP1, VP2, and VP3, wherein the modification brings about a reduction in the antigenicity of the virus relative to wild-type AAV and wherein the modified structural protein forms AAV particles and the AAV having the modified structural protein retains infectivity, and further wherein the modification(s) is/are located directly adjacent to at least one amino acid in a sequence selected from the group consisting of YKQIS SQSGA (SEQ ID NO:

• 2), YLTLN NGSQA (SEQ ID NO:
• 3), YYLSR TNTPS (SEQ ID NO:
• 4), EEKFF PQSGV (SEQ ID NO:
• 5), NPVAT EQYGS (SEQ ID NOS:
• 6, 7), LQRGN RQAAT (SEQ ID NO:
• 8), and NVDFT VDTNG (SEQ ID NO:
• 9).