Tissue engineering enhanced by the transfer of a growth factor gene
AssigneesMassachusetts Institute of Technology, The General Hospital Corporation
InventorsHenning Madry, Gordana Vunjak-Novakovic, Stephen B. Trippel, Lisa E. Freed, Robert Langer
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Abstract
Tissue engineered constructs including a matrix and cells transfected with a gene for a growth factor. The constructs may be implanted into a tissue site, where the growth factor gene enhances a metabolic function furthering integration of the construct in the tissue site. If the matrix is biodegradable, the metabolic result may include resorption of the matrix and replacement with tissue synthesized at least in part by the transfected cells.
Claims11
A method of assembling a tissue engineered articular cartilage construct, comprising:
- transfecting a plurality of chondrocytes with a gene for insulin-like growth factor I (IGF-I);
- and
- seeding the transfected cells onto a biocompatible matrix comprising poly(glycolic acid),
- wherein at least a portion of the transfected cells synthesize collagen type II.
A tissue engineered construct, comprising:
- a plurality of chondrocytes transfected with a gene for IGF-I, and
- a biocompatible matrix comprising poly(glycolic acid),
- wherein the construct is characterized by synthesis of collagen type II.
Dependencies are inferred from the claim text.