Glutamate transporter associated proteins and methods of use thereof
AssigneeThe Johns Hopkins University
InventorsJeffrey D. Rothstein, Mandy Jackson, Glen Lin, Robert Law, Irina Orlov
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Abstract
Glutamate Transporter Associated Proteins and nucleotide encoding Glutamate Transporter Associated Proteins are provided. Also provided is a method for identifying a compound that modulates a cellular response mediated by a Glutamate Transporter Associated Protein. A method is further provided for identifying a compound that inhibits an interaction between a Glutamate Transporter Associated Protein and a glutamate transporter protein. A method is provided for treating a disorder associated with glutamate transport.
Claims8
An isolated polynucleotide selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide having the amino acid sequence as set forth in SEQ ID NO:6;
- (b) a polynucleotide of (a), wherein all T's are replaced by U's;
- (c) a polynucleotide complementary to the full length polynucleotide of (a);
- and
- (d) a polynucleotide having the nucleotide sequence as set forth in SEQ ID NO:5.
Dependencies are inferred from the claim text.