Interferon-like protein Zcyto21
AssigneeZymoGenetics, Inc.
InventorsPaul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
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Abstract
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-α at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
Claims25
An isolated nucleic acid molecule encoding a zcyto21 polypeptide, wherein the encoded polypeptide has at least 95% sequence identity to amino acid residues 20-200 of SEQ ID NO:2, and wherein the encoded polypeptide inhibits hepatitis B or C replication.
An isolated polynucleotide molecule comprising a nucleic acid molecule that is capable of hybridizing under stringent wash conditions in a solution of 0.1-0.2×SSC with 0.1% sodium dodecyl sulfate at 50-65° C. to a nucleic acid molecule consisting of the nucleotide sequence of nucleotides 58 to 603 of SEQ ID NO:1, or the complement of the nucleotide sequence of nucleotides 58 to 603 of SEQ ID NO:
- 1, wherein the polynucleotide encodes a protein that inhibits hepatitis B or C replication.
Dependencies are inferred from the claim text.